Our fundamental premise is that innovative methods, analytical rigor, and scientific acumen can be provided in a commercial entity that operates “at the speed of business.” Monument Analytics delivers.

Unparalleled Knowledge Base

One of the most remarkable features of Monument Analytics is its access to consultants with an unparalleled knowledge base. Through its independent consulting services, Monument Analytics leverages this acumen to assist clients developing products and services for the benefit of society.

Top Notch Evidence

By capitalizing on this unparalleled depth and breadth of human capital, Monument Analytics is able to generate the highest quality evidence regarding the safety, effectiveness, and real-world value of the full range of medical processes and technologies; and to use this knowledge to help our clients navigate evermore complex and challenging regulatory and payment environments.

Internationally Renowned Experts

Our Principals and Consultants are internationally renowned for their expertise in areas ranging from epidemiology and biostatistics to clinical fields such as cardiovascular medicine, oncology, and immunology.

G. Caleb Alexander
G. Caleb AlexanderMD, MS
Jonothan C. Tierce
Jonothan C. TierceCPhil
William V. Padula
William V. PadulaPhD
Natalie Reid
Natalie ReidPhD, MPH, MBA


Our services are broadly organized into four core capabilities

  • Comparative effectiveness analyses
  • Pharmacovigilance and safety assessments
  • Investigations of drug utilization
  • Risk-benefit appraisals
  • Bayesian, meta-analytic and systematic reviews
  • Patient and clinician preferences
  • Global marketplace and pharmaceutical policy
  • Design and conduct of sophisticated comparative effectiveness, pharmacovigilance, and drug utilization studies
  • Advanced techniques for causal inference, management of missing data, and other statistical analysis
  • Cost-benefit analysis and cost-effectiveness analysis
  • Natural history of disease and resource utilization
  • Systematic economic and quality-of-life reviews
  • Core value dossiers

MA in the News

May 17, 2022  Bill Padula
Monument Analytics Co-Founder and Principal Dr. Caleb Alexander participated in an educational symposium sponsored by IBM Watson Health titled: “Downstream Effects of Pandemic-Related Disruptions in Healthcare Utilization and Cost: Insights from Healthcare Claims and Survey Data” at ISPOR 2022.

May 16, 2022  Bill Padula
Monument Analytics Principal Dr. Bill Padula was the discussion leader of a breakout session titled: “How to Apply Machine Learning to Health Economics and Outcomes Research: Findings from the ISPOR Machine Learning Task Force” at ISPOR 2022.

May 10, 2022  Caleb Alexander
Monument Analytics Co-Founder and Principal Dr. Caleb Alexander’s abatement plan was discussed in an article in the Star Tribune titled: “Judge to decide how much pharmacies owe over opioid crisis.”

March 30, 2022  Caleb Alexander
Monument Analytics Co-Founder and Principal Dr. Caleb Alexander was quoted in The New York Times article titled: “New A.L.S. Treatment Lacks Evidence of Benefit, F.D.A. Panel Finds.”.

March 20, 2022  Caleb Alexander
Monument Analytics Co-Founder and Principal Dr. Caleb Alexander was interviewed in a segment of Full Measure with Sharyl Attkisson titled: “Mind Games” about the FDA’s approval of Aduhelm.